diff --git a/config.sub b/config.sub
index d74fb6d..e5e15e4 100755
--- a/config.sub
+++ b/config.sub
@@ -1748,7 +1748,7 @@ case $os in
 	     | skyos* | haiku* | rdos* | toppers* | drops* | es* \
 	     | onefs* | tirtos* | phoenix* | fuchsia* | redox* | bme* \
 	     | midnightbsd* | amdhsa* | unleashed* | emscripten* | wasi* \
-	     | nsk* | powerunix* | genode* | zvmoe* | qnx* | emx* | zephyr*)
+	     | nsk* | powerunix* | genode* | zvmoe* | qnx* | emx* | zephyr* | ohos*)
 		;;
 	# This one is extra strict with allowed versions
 	sco3.2v2 | sco3.2v[4-9]* | sco5v6*)
@@ -1786,6 +1786,8 @@ case $kernel-$os in
 		;;
 	*-eabi* | *-gnueabi*)
 		;;
+	*-ohos*)
+		;;
 	-*)
 		# Blank kernel with real OS is always fine.
 		;;
diff --git a/configure.ac b/configure.ac
index 1c25abd..1f5a417 100644
--- a/configure.ac
+++ b/configure.ac
@@ -941,6 +941,8 @@ cat > conftest.c <<EOF
 # elif defined(__aarch64__) && defined(__AARCH64EL__)
 #  if defined(__ILP32__)
         aarch64_ilp32-linux-gnu
+#  elif defined(__OHOS__)
+        aarch64-linux-ohos
 #  else
         aarch64-linux-gnu
 #  endif
@@ -959,8 +961,10 @@ cat > conftest.c <<EOF
         armeb-linux-gnueabihf
 #  endif
 # elif defined(__ARM_EABI__) && !defined(__ARM_PCS_VFP)
-#  if defined(__ARMEL__)
+#  if defined(__ARMEL__) && !defined(__OHOS__)
         arm-linux-gnueabi
+#  elif defined(__OHOS__)
+        arm-linux-ohos
 #  else
         armeb-linux-gnueabi
 #  endif
@@ -1096,7 +1100,7 @@ AC_MSG_CHECKING([for multiarch])
 AS_CASE([$ac_sys_system],
   [Darwin*], [MULTIARCH=""],
   [FreeBSD*], [MULTIARCH=""],
-  [MULTIARCH=$($CC --print-multiarch 2>/dev/null)]
+  [MULTIARCH=$($CC $CFLAGS --print-multiarch 2>/dev/null)]
 )
 AC_SUBST([MULTIARCH])
 AC_MSG_RESULT([$MULTIARCH])
diff --git a/setup.py b/setup.py
index 4f122b6..fbff78a 100644
--- a/setup.py
+++ b/setup.py
@@ -56,7 +56,7 @@
 
 
 # This global variable is used to hold the list of modules to be disabled.
-DISABLED_MODULE_LIST = []
+DISABLED_MODULE_LIST = ['_uuid', '_socket', 'zlib', '_ctypes', 'binascii']
 
 # --list-module-names option used by Tools/scripts/generate_module_names.py
 LIST_MODULE_NAMES = False
@@ -849,10 +849,11 @@ def configure_compiler(self):
         if not CROSS_COMPILING:
             add_dir_to_list(self.compiler.library_dirs, '/usr/local/lib')
             add_dir_to_list(self.compiler.include_dirs, '/usr/local/include')
+            self.add_multiarch_paths()
         # only change this for cross builds for 3.3, issues on Mageia
         if CROSS_COMPILING:
             self.add_cross_compiling_paths()
-        self.add_multiarch_paths()
+        self.compiler.add_library('python%s' % sys.version.split()[0][:4])
         self.add_ldflags_cppflags()
 
     def init_inc_lib_dirs(self):
diff --git a/support_ohos_ignorefile.txt b/support_ohos_ignorefile.txt
new file mode 100644
index 0000000..e69de29